Subtype | Agonist | Antagonist | IC50 | Hill coef. | Kb |
---|---|---|---|---|---|
μm | μm | ||||
GluR1 | AMPA (1 μm) | AMOA | 253 ± 25 | 1.1 ± 0.1 | 57 |
GluR1 | KA (25 μm) | AMOA | 62 ± 3.9 | 1.2 ± 0.08 | 44 |
GluR1/2 | KA (25 μm) | AMOA | 97 ± 3.4 | 1.5 ± 0.03 | 76 |
GluR1 | AMPA (1 μm) | ATPO | 22 ± 1.8 | 0.71 ± 0.04 | 4.9 |
GluR1 | KA (25 μm) | ATPO | 5.3 ± 0.8 | 0.82 ± 0.04 | 3.9 |
GluR1/2 | KA (25 μm) | ATPO | 6.6 ± 0.21 | 1.2 ± 0.04 | 5.2 |
GluR1/2 | Glu (10 μm) | ATPO | 10 ± 0.66 | 0.90 ± 0.3 | 7.9 |
GluR3 | KA (20 μm) | ATPO | 12 ± 0.38 | 1.2 ± 0.1 | 15 |
GluR4 | KA (20 μm) | ATPO | 34 ± 2.8 | 0.96 ± 0.04 | 26 |
Analysis of concentration-inhibition experiments. IC50 values and Hill coefficients are from the best fit of the data to eq. 1.K b values were estimated using a Leff-Dougall approach (see Materials and Methods).