Tissue | Genotype | N | Renal activity | H/C ratio |
---|---|---|---|---|
Kidney | 314C/C | 92 | 33.6 ± 0.82-a | 0.51 ± 0.0052-a |
314C/T | 20 | 24.9 ± 1.0 | 0.45 ± 0.012 | |
314T/T | 2 | 14.8 | 0.27 | |
RBC | 314C/C | 27 | 744 ± 462-b | 0.47 ± 0.0132-b |
314C/T | 5 | 385 ± 51 | 0.41 ± 0.012 | |
Kidney | 939A/A | 71 | 34.3 ± 0.92-c | 0.51 ± 0.0062-c |
939A/G | 38 | 28.4 ± 1.22-c | 0.48 ± 0.009 | |
939G/G | 5 | 20.2 ± 2.52-c | 0.42 ± 0.68 | |
RBC | 939A/A | 21 | 740 ± 58 | 0.48 ± 0.016 |
939A/G | 10 | 609 ± 71 | 0.44 ± 0.013 | |
939G/G | 1 | 378 | 0.38 |
Values for HNMT activities and H/C ratios are mean ± standard error. Renal activity is given in nmol/hr/mg of protein, and RBC activity is given in pmol/hr/ml of RBCs.
↵2-a p < 0.0001 compared with values for heterozygous renal samples.
↵2-b p = 0.03 compared with values for heterozygous RBC samples.
↵2-c p < 0.05 compared with the other two genotypes for that polymorphism within the renal samples.