Table 2

HNMT genotype at nucleotides 314 and 939 and their relationship to phenotype

TissueGenotypeNRenal activityH/C ratio
Kidney 314C/C 9233.6  ± 0.82-a 0.51  ± 0.0052-a
314C/T 2024.9  ± 1.00.45  ± 0.012
314T/T 214.80.27
RBC 314C/C 27744  ± 462-b 0.47  ± 0.0132-b
314C/T 5385  ± 510.41  ± 0.012
Kidney 939A/A 7134.3  ± 0.92-c 0.51  ± 0.0062-c
939A/G 3828.4  ± 1.22-c 0.48  ± 0.009
939G/G 520.2  ± 2.52-c 0.42  ± 0.68
RBC 939A/A 21740  ± 580.48  ± 0.016
939A/G 10609  ± 710.44  ± 0.013
939G/G 13780.38
  • Values for HNMT activities and H/C ratios are mean ± standard error. Renal activity is given in nmol/hr/mg of protein, and RBC activity is given in pmol/hr/ml of RBCs.

  • 2-a p < 0.0001 compared with values for heterozygous renal samples.

  • 2-b p = 0.03 compared with values for heterozygous RBC samples.

  • 2-c p < 0.05 compared with the other two genotypes for that polymorphism within the renal samples.