Effect of GPP(NH)P on 3H-LTC4 and3H-LTD4 binding
| Ligand | Kd1 ± CV% | Kd2 ± CV% | Bmax1 ± CV% | Bmax2 ± CV% |
|---|---|---|---|---|
| nm | pmol/mg | |||
| 3H-LTC4 | 0.039 ± 40 | 102 ± 49 | 0.0012 ± 55 | 2.5 ± 50 |
| 3H-LTD4 | 0.037 ± 50 | 22 ± 43 | 0.0007 ± 22 | 0.33 ± 42 |
| + 30 μmGPP(NH)P | ||||
| 3H-LTC4 | 0.039 ± 71 | 86 ± 74 | 0.0008 ± 50 | 1.9 ± 77 |
| 3H-LTD4 | 30 ± 40 | 0.3 ± 42 | ||