Table 4

Thermodynamic parameters for tubulin-vinca alkaloid interaction at 25°

	Ligand-mediated
	K₁K₂	ΔG°	ΔS°	ΔH°
	m ⁻²	kcal/mol	cal/mol−°K	kcal/mol
Vinorelbine
GTP	1.4 × 10¹¹	−15.2	76	7.4^4-a
GDP	6.6 × 10¹¹	−16.1	69	4.4^4-a
Vinflunine
GTP	2.6 × 10¹⁰	−14.2	98	15.1^4-a
GDP	1.2 × 10¹¹	−15.1	87	10.9^4-a

↵4-a Data from three temperatures only (5°, 15°, and 25°).