Drug | 125I-CYP bindingKi | cAMP accumulation | |
---|---|---|---|
pEC50 | Intrinsic activity | ||
nm | nm | ||
ISO | 6.7 ± 0.1 | 8.2 ± 0.3 | 1.0 |
NE | 5.4 ± 0.1 | 6.9 ± 0.1 | 1.07 ± 0.07 |
DOB | 5.3 ± 0.1 | 6.3 ± 0.2 | 0.68 ± 0.11 |
BRL | 6.6 ± 0.2* | 7.3 ± 0.5* | 0.39 ± 0.06 |
CL | 5.7 ± 0.2* | 6.7 ± 0.2* | 0.53 ± 0.07* |
Values are means ± SE for four to five experiments.
* Significantly different from β1-AR.