Table 2

Inhibitory effects of fluoroquinoline derivatives on HIV-1 replication in MT-4 and MOLT-4 cells

CompoundCellEC502-aIC502-bSI2-c
μm
K-12MT-40.64  ± 0.065.4  ± 0.88.4
MOLT-40.11  ± 0.078.1  ± 1.574
K-37MT-40.20  ± 0.060.53  ± 0.052.7
MOLT-40.020  ± 0.0101.6  ± 0.280
K-38MT-40.043  ± 0.0150.12  ± 0.052.8
MOLT-40.0090  ± 0.00300.22  ± 0.0924
K-42MT-40.93  ± 0.413.5  ± 0.63.8
MOLT-40.18  ± 0.069.7  ± 1.254
3TCMT-40.63  ± 0.32>20>32

All data represent mean values ± standard deviation for at least three separate experiments.

  • ↵2-a Based on the inhibition of virus-induced cytopathicity.

  • ↵2-b Based on the reduction of viable cell number in mock-infected cells.

  • ↵2-c Ratio of IC50 to EC50.