The pharmacology of the benzodiazepine binding site after photoincorporation of flunitrazepam
| Compound | Ki before flunitrazepam incorporation | Ki after flunitrazepam incorporation |
|---|---|---|
| nm | ||
| Ro 15-1788 | 1.3 ± 0.02 | 1.2 ± 0.03 |
| Ro 15-4513 | 4.2 ± 0.9 | 1.3 ± 0.1 |
| Flunitrazepam | 4.2 ± 0.2 | 230.0 ± 2 |
| Midazolam | 3.4 ± 0.2 | 249.0 ± 9.0 |
| Diazepam | 14.9 ± 1.2 | >1000 nm |
| Zolpidem | 17.4 ± 1.5 | 21.8 ± 2.5 |
| β-CCM | 1.2 ± 0.1 | 0.9 ± 0.03 |
| L-655,708 | 42.3 ± 7.8 | 46.2 ± 23 |
| CGS-8216 | 0.05 ± 0.008 | 0.06 ± 0.003 |
| Chlordiazepoxide | 177 ± 34 | >1000 m |
| Abecarnil | 0.85 ± 0.06 | 1.6 ± 0.1 |
| L-764,488 | 2.48 ± 0.14 | 64.8 ± 0.7 |
| L-763,673 | 0.31 ± 0.01 | 31.3 ± 0.2 |
| L-816,993 | 24.5 ± 1.6 | 25.5 ± 3.3 |
| Pyridoindole 1 | 5.0 ± 0.5 | 8.2 ± 1.3 |
| Pyridoindole 2 | 2.4 ± 0.4 | 3.5 ± 0.1 |
Data shown are the mean ± standard error of three to five experiments.