Lack of cross resistance of chloroquine and resistance modulators
| Strain | CQ IC50 | VP IC50 | PQ IC50 | DAU IC50 |
|---|---|---|---|---|
| nm | μm | μm | nm | |
| K1 | 210 ± 38 | 16.7 | 2.04 | 310 |
| TM6 | 128 ± 33 | 13.8 | 2.03 | 257 |
| TM5 | 112 ± 27 | 21.3 | 5.13 | 395 |
| 1952 | 30 ± 5.8 | 20.1 | 4.3 | 420 |
| HB3 | 13 ± 2.6 | 5.05 | 23.1 | 365 |
The chloroquine data represent mean ± standard deviation of data from five separate sensitivity assays, each performed in triplicate. Data for the other drugs represents mean values of two separate sensitivity assays, each performed in triplicate.