Table 1

COMPARE analysis of NSC 314622 using GI50 data from the National Cancer Institute In Vitro Anticancer Drug Screen

Rank	NSC	LHICONC	Max X	CORR	N	Mechanism/class
1	314622	−4.00	5	1.000	60	top1
2	D	−4.00	3	0.845	60	top1
3–35				0.842–0.778		33 camptothecins
36	9706	−4.00	137	0.777	60	alkylating agent
37	D	−4.00	3	0.776	60	1 camptothecin
38	D	−4.00	2	0.775	59	analog NSC 314622
39	132313	−3.00	4	0.775	60	alkylating agent
40–52				0.774–0.765		12 camptothecins
53	D	−4.00	2	0.764	60	alkylating agent
54–61				0.763–0.760		8 camptothecins
62	167781	−4.00	4	0.760	60	alkylating agent
63–71				0.759–0.751		9 camptothecins
72	638436	−4.00	1	0.751	40	top1 and/or top2
73–74				0.751–0.750		2 camptothecins
75	3088	−3.12	127	0.749	60	alkylating agent
76	6396	−3.00	130	0.748	60	alkylating agent
77–79				0.747		3 camptothecins
80	620480	−4.00	3	0.747	58	alkylating agent
81	D	−4.00	2	0.744	60	bleomycin analog
82–91				0.744–0.740		10 camptothecins
92	48034	−4.00	2	0.739	59	alkylating agent
93	D	−6.00	2	0.739	58	alkylating agent
94	D	−4.12	2	0.739	59	1 camptothecin
95	275656	−4.00	3	0.738	57	alkylating agent
96–100				0.737–0.734		5 camptothecins

NSC, number key to the NCI database (D indicates discrete compound); LHICONC, decimal logarithm of the highest drug concentration tested (molar concentration); Max X, measure of the number of tests that were averaged for this compound; CORR, Pearson coefficient for the seed and the data base compound; and N, number of cell lines common to both the seed and the database compound, which therefore are used in the calculation of the CORR.