Binding affinities for the hydroxylated derivatives of AEA for the two subtypes of cannabinoid receptor
| Ligand | Ki | |
|---|---|---|
| CB1 | CB2 | |
| nm | ||
| AEA | 107 ± 54 | 94 ± 9 |
| 12-(S)-HAEA | 207 ± 52 | 131 ± 20 |
| 12-(R)-HAEA | 416 ± 14 | >1000 |
| 15-(S)-HAEA | 738 ± 109 | >1000 |
| 20-HAEA | 103 ± 19 | 451 ± 76 |
| Compound D-EA | 1800 ± 100 | 223 ± 78 |
| Win 55212-2 | 2.8 ± 1.7 | 1.6 |
Binding affinities were determined by competition with [3H]CP55940 to either rat brain membranes (CB1 receptor) or membranes from CHO cells transfected with the human CB2 receptor. Data represent mean ± standard error of three determinations.