Table 3

Comparison of predictions of the three-state model with experimental data

AgonistpEC50Emaxagonist/Emax 5-HTL = M = 100
IPAAIPAAKAKA*KA**
ActualModelActualModelActualModelActualModel
5-HT7.437.397.347.391.001.001.001.001.00E-058.00E-108.00E-10
bufotenin6.506.396.336.390.780.791.081.131.00E-051.00E-087.00E-09
DOI6.726.766.806.760.610.610.970.968.00E-075.60E-093.60E-09
LSD7.808.098.118.090.170.160.390.401.10E-081.00E-094.00E-10
quipazine5.896.046.066.040.890.890.590.603.50E-062.00E-083.00E-08
TFMPP6.346.436.486.431.021.030.590.602.00E-067.00E-091.20E-08

Computer simulations with the three-state model were done as described in the text. “Actual” data are from experiments with 5-HT2Creceptor-mediated IP accumulation and AA release (Fig. 4 and Table 1). The values obtained from computer simulations (model) closely approximate the experimental data (actual).