Table 1

Comparison of ethanol effects on BK channel gating in various preparations (results are expressed as percentages of pre-ethanol values).

	I/O Patches		T-tubule BK Channel
	Neurohypophyseal BK channels^1-a	α mslo (mbr5) in Xenopusoocytes^1-b	PE/PS bilayer	PE bilayer
NP _o	457.8 ± 60.3	268.7 ± 27.8	825.6 ± 528.5	426.1 ± 154.3
t _o	128.7 (72.6, 175.4)	159.6 ± 22.4	106.3 (94.1, 118.5)	131.1 (120.5, 141.5)
t _c	58.3 (49.3, 67.2)	54.2 ± 4.8	24.5 (8.4, 39.7)	40.6 (22.8, 58.5)

Measurements were performed before and during exposure (≤1 min) to 50 mm ethanol. Each value is the mean ± standard error of 6–20 determinations; each determination was obtained in a different patch/bilayer. In cases in which n = 2, both the average and the individual values (in parentheses) are given. In all cases, the free [Ca⁺⁺]_ic was adjusted such that theNP _o was <0.5. The compositions of the solutions used are described in Materials and Methods or in the references cited.

NP _o, steady state activity;t _o, mean open time; t _c, mean closed time.
↵1-a From Dopico et al., 1996.
↵1-b From Dopico et al., 1998.