Table 1

Swimming speed of different treatment groups during visible and hidden platform training days.

GroupVisible platform trainingHidden platform training
cm/sec
WT saline (ATI)17.47  ± 1.9717.00  ± 3.40
OE saline (ATI)13.96  ± 2.691-b 14.12  ± 3.441-b
WT ATI 3017.84  ± 2.0919.62  ± 2.42
OE ATI 3012.21  ± 2.9512.33  ± 3.99
WT ATI 30015.27  ± 3.561-a 17.19  ± 3.46
OE ATI 30012.52  ± 2.8214.58  ± 3.91
WT saline (DEX)20.94  ± 2.3921.66  ± 2.39
OE saline (DEX)16.71  ± 1.781-b 17.97  ± 1.90†
WT DEX 0.520.20  ± 1.6620.85  ± 2.44
OE DEX 0.517.00  ± 1.6518.30  ± 3.48
WT DEX 220.43  ± 2.3621.73  ± 2.44
OE DEX 216.56  ± 3.2219.49  ± 3.13
WT DEX 518.24  ± 1.351-a 18.87  ± 1.601-a
OE DEX 515.41  ± 1.6917.03  ± 2.90

OE mice swam slower than WT mice during all of the training stages. ATI 30 μg/kg had no effect on swimming speed. ATI 300 μg/kg decreased swimming speed during visible platform training but not during hidden platform training.

DEX 0.5–2 μg/kg had no effect on swimming speed, whereas DEX 5 μg/kg decreased swimming speed. Mean ± standard deviation values for 5 training days are shown.

    • ↵1-a p < 0.05 vs. saline-treated own control (WT or OE) mice.

    • ↵1-b p < 0.05 vs. saline-treated WT control mice.