Table 1

Effect of fasting-refeeding on physiological parameters and P450 content in rats

Treatment	Body weight		Plasma		Urine ketone		Liver P450
Treatment	Prefast	Postfast	Glucose	β-Hydroxybutyrate	Insulin	Fasted	Liver P450	Refed
	g		mg/dl	mg/dl	ng/ml	units		nmol/mg protein
Fed	314 ± 5	312 ± 5	166 ± 5	4.9 ± 0.3	2.6 ± 0.2	0		0.58 ± 0.07
F48	315 ± 11	282 ± 11	148 ± 13	21.5 ± 1.0^1-a	1.2 ± 0.3^1-a	2.6 ± 0.1^1-a		0.52 ± 0.06
F48/R6	313 ± 13	284 ± 12	210 ± 18^1-a	3.7 ± 0.2	2.5 ± 0.3	2.6 ± 0.1^1-a	1.3 ± 0.1^1-b	0.53 ± 0.06
F48/R24	312 ± 8	286 ± 9	171 ± 5	3.3 ± 0.5	2.2 ± 0.3	2.6 ± 0.1^1-a	1.1 ± 0.2^1-b	0.53 ± 0.07

Male Fisher 344 rats were either fed, fasted 48 hr (F48), fasted 48 hr/refed 6 hr (F48/R6), or fasted 48 hr/refed 24 hr (F48/R24) as described in Experimental Procedures. Values are mean ± standard error from 7 rats in each group.

↵1-a p < 0.05 for comparison with fed in the same column by ANOVA.
↵1-b p < 0.05 for comparison with fasted in the same row by Student’s t test.