Levels of mRNA encoding adenylyl cyclase isoforms in LMMP tissue obtained from opiate naive and chronic morphine-treated guinea pigs
| AC isoform | Isoform mRNA/total RNA | |
|---|---|---|
| Opiate naive | Chronic morphine | |
| pg/μg | ||
| AC II | 0.93 ± 0.16 (4) | 1.0 ± 0.1 (4) |
| AC I1-a | 0.64 ± 0.14 (4) | 0.71 ± 0.13 (4) |
| AC IV1-a | 0.49 ± 0.04 (4) | 0.67 ± 0.041-b (4) |
Data are represented as mean ± standard error pg equivalents/μg of total RNA. The number of animals in each group is indicated in parentheses.
↵1-a Reprinted from Molecular Brain Research (1998)54: 165–169 by Rivera and Gintzler, with permission from Elsevier Science.
↵1-b p < 0.05 for AC IV mRNA in chronic morphine-treated tissue versus control.