Effect of staurosporine and its analogs on size of rat thymocytes.
| Treatment | Concentration | Mean cell diameter |
|---|---|---|
| μm | μm | |
| None | 6.48 | |
| Staurosporine | 1 | 5.32 |
| UCN-01 | 10 | 5.62 |
| UCN-02 | 10 | 5.84 |
| CGP 41251 | 10 | 6.48 |
| RO 31-8220 | 10 | 6.45 |
| GF 109203X | 10 | 6.51 |
Cells were incubated with agents for 4 hr and mean cell diameter was estimated as described in Materials and Methods. Results are the mean of three determinations in an experiment representative of four in the case of the control cells and of two experiments for the drug-treated cells.