Summary of assays performed to evaluate the ability of a compound to interact with MRP
| NSC number | Correlation coefficient | Relative resistance MCF7/VP | Relative resistance ZR/VP13 | Inhibition of calcein efflux MCF7/VP | Inhibition of calcein efflux UMCC-1/VP | Inhibition of LTC4 uptake |
|---|---|---|---|---|---|---|
| 26040 | 0.525 | 1 | 1 | |||
| 59193 | 0.501 | 1.3 | 1.9 | 111 | 88 | |
| 189793 | 0.489 | 1.5 | 3.9 | 289 | 286 | 73 |
| 288010 | 0.548 | 6.8 | 1 | 201 | 1371-a | 29 |
| 600684 | 0.487 | 2.3 | 9.4 | 195 | 262 | 34 |
| 601101 | 0.516 | 1 | 1 | 2051-a | 1-a | |
| Discreet | 0.513 | 1 | 1 | 1-a | 1091-a | |
| 610686 | 0.518 | 2.4 | 2.1 | 202 | 188 | |
| 617130 | 0.456 | 1 | 1 | 217 | 138 | 10 |
| 617131 | 0.489 | 1.2 | 4.3 | 139 | 153 | |
| 626482 | 0.529 | 2 | 1 | 429 | 195 | 83 |
| 626551 | 0.576 | 1 | 1.7 | 122 | ||
| 627991 | 0.568 | 4 | 2.2 | Fluorescent | Fluorescent | 80 |
| Discreet | 0.486 | 1 | 2 | Insoluble | Insoluble | Insoluble |
| 639859 | 0.615 | 1 | 1.4 | 1291-a | 122 | |
| Discreet | 0.433 | 1 | 1 | 1641-a | 1-a | 90 |
| 643318 | 0.488 | 1 | 2.5 | 239 | 365 | 25 |
| 653506 | 0.494 | 1 | 1.3 | 186 | 131 | |
| 654819 | 0.481 | 1 | 1 | 343 | 319 | 86 |
| 654968 | 0.612 | 1 | 1 | 107 | ||
| 656471 | 0.487 | 1 | 1.4 | |||
| 657799 | 0.511 | 1 | 1 | 286 | 183 | 35 |
| 661418 | 0.511 | 1.8 | 1.3 | 1-a | 1651-a | |
| Discreet | 0.435 | 1 | 1 | 138 | 106 |
Pearson’s correlation coefficient obtained by comparing the drug cytotoxicity profile with that of MRP expression as described in the text. Relative resistance is defined as the ratio of the IC50values (MCF7/VP:MCF7; ZR/VP13:ZR-75B). Inhibition of calcein efflux values are given as percentage change of calcein accumulation. Inhibition of LTC4 uptake number represents the percent decrease with 100% maximum.
↵1-a Toxic at 100 μm.