Activation | Inactivation | |||||
---|---|---|---|---|---|---|
Cells | V0.5 | k | Cells | V0.5 | k | |
mV | mV | |||||
HERG | ||||||
Control | 11 | −13.9 ± 1.1 | 8.4 ± 0.3 | 11 | −26.1 ± 4.6 | 17.8 ± 0.6 |
Verapamil (1 μM) | −21.9 ± 2.11-a | 7.9 ± 0.3 | −48.4 ± 4.51-a | 20.2 ± 0.7 | ||
Control | 10 | −12.1 ± 2.1 | 8.1 ± 0.4 | 10 | −32.7 ± 6.3 | 16.7 ± 1.1 |
Bepridil (0.5 μM) | −20.2 ± 2.51-a | 7.2 ± 0.4 | −54.3 ± 7.11-a | 18.9 ± 1.2 | ||
Control | 10 | −13.1 ± 1.2 | 8.4 ± 0.6 | 8 | −35.9 ± 5.2 | 16.0 ± 0.7 |
Mibefradil (1 μM) | −21.1 ± 1.31-a | 7.7 ± 0.2 | −60.0 ± 4.31-a | 17.5 ± 0.8 | ||
KvLQT1/IsK | ||||||
Control | 8 | 32.0 ± 3.6 | 26.2 ± 1.5 | |||
Bepridil (10 μM) | 34.3 ± 5.5 | 21.8 ± 1.7 | ||||
Control | 6 | 20.0 ± 3.5 | 23.1 ± 2.0 | |||
Mibefradil (10 μM) | 23.3 ± 1.1 | 20.3 ± 1.2 |
Data are expressed as mean ± standard error. Values of V0.5 and k were obtained with a Boltzmann function.
↵1-a Statistically significant difference (p < 0.05) compared with control.