Bold, divergent amino acids between h5-HT1D and h5-HT1B receptors. For convenience, the first and last residues (arrows) of TMD V are numbered as 501 and 524 as referred to in Discussion. The corresponding K i values for the inhibition of radioligand binding by ketanserin to each of these receptor subtypes were obtained using [3H]5-HT, [3H]5-CT, or [3H]ketanserin as a radioligand.
ca, canine; rb, rabbit; gp, guinea pig.
6-a [3H]5-HT.
6-b [3H]5-CT.
6-c [3H]ketanserin.