Table 6

Amino acid sequences of the putative second ECL and fifth TMD of canine, guinea pig, rabbit, and h5-HT1B and h5-HT1Dreceptors and 5-HT2A receptor

graphic

Bold, divergent amino acids between h5-HT1D and h5-HT1B receptors. For convenience, the first and last residues (arrows) of TMD V are numbered as 501 and 524 as referred to in Discussion. The corresponding K i values for the inhibition of radioligand binding by ketanserin to each of these receptor subtypes were obtained using [3H]5-HT, [3H]5-CT, or [3H]ketanserin as a radioligand.

    • ca, canine; rb, rabbit; gp, guinea pig.

    • 6-a [3H]5-HT.

    • 6-b [3H]5-CT.

    • 6-c [3H]ketanserin.