Table 2

Ability of l-type calcium channel blockers injected i.c.v. to prevent restraint-induced tottering mouse dystonic episodes

Drug Injection, i.c.v.	% Tottering Mice Exhibiting Dystonia
Saline vehicle	64% (n = 11)
Verapamil, 10 μg	20%^1-a (n = 10)
Diltiazem, 20 μg	0%^1-b (n = 6)

The specific l-type calcium channel blockers verapamil and diltiazem each significantly reduced the occurrence of restraint-induced tottering mouse dystonic episodes. Data are expressed as % dystonic events observed.

↵1-a P < .05 versus saline vehicle control by ANOVA followed by Dunnett t-test.
↵1-b P < .01 versus saline vehicle control by Student’s t test.