Quantitative analysis of calcium channel α1C subunit mRNA expression in control (+/+) and tottering (tg/tg) mouse brain
| Brain Region | +/+ | tg/tg |
|---|---|---|
| Cerebellar Purkinje cell layer (Lobule VIII) | 110.6 ± 3.6 (11) | 132.6 ± 3.6 (11)** |
| Cerebellar granule cell layer (Lobule VIII) | 107.6 ± 3.7 (11) | 110.4 ± 4.3 (11) |
| Deep cerebellar nuclei | 68.5 ± 1.7 (11) | 74.3 ± 3.0 (11) |
| Nucleus of the brachium of the inferior colliculus | 80.3 ± 3.5 (7) | 98.3 ± 4.4 (6)3-150 |
| Medical geniculate nucleus | 75.8 ± 2.7 (10) | 83.3 ± 4.4 (9) |
| Thalamic ventrobasal complex | 73.0 ± 2.5 (11) | 78.2 ± 3.1 (10) |
| Hippocampal dentate gyrus | 59.1 ± 2.1 (11) | 58.9 ± 2.5 (11) |
| Cerebral cortex | 57.8 ± 3.3 (11) | 67.2 ± 3.8 (11) |
| Olfactory bulb | 83.5 ± 4.9 (11) | 78.8 ± 4.1 (11) |
Data represent mean ± S.E.M. (n = 3) with number of sections assessed in parentheses. Granule cell and Purkinje cell assessments were also performed in Lobule V of the cerebellum with similar results. An increase in cerebral cortex expression was also observed, but this trend did not reach significance (P< .1).
↵3-150 P < .01 and ** P < .001 as determined by two-tailed Student’s t test.