Distribution of single-channel closed times in WT and Q266H GlyRs
| Closed Times | Mean ± S.E.M. | τ1 | τ2 | τ3 | ||||
|---|---|---|---|---|---|---|---|---|
| ms | ms | % | ms | % | ms | % | ||
| WT | 113 ± 35.0 | 0.40 ± 0.13 | 38 ± 13 | 5.92 ± 2.82 | 21 ± 4.4 | 185 ± 49.1 | 41 ± 10 | |
| Q266H | 37.6 ± 15.2 | 0.63 ± 0.29 | 26 ± 2.7 | 4.31 ± 1.09 | 25 ± 1.6 | 32.2 ± 10.1* | 50 ± 3.8 | |
Closed-time distribution of the main conductance state in single-channel openings in WT and Q266H GlyRs recorded at −60 mV in response to low doses of glycine. Significant difference (p < 0.05) between WT and Q266H is indicated by an asterisk. Data are presented as described in the legend to Table 2.