Table 1

Response characteristics and kinetic parameters

AmplitudeD/PDesensitization Half-timen
pA ms
PP1-a 45  ± 100.11  ± 0.05300  ± 707
IL1-b
 High sensitivity530  ± 800.25  ± 0.065420  ± 8806
 Low sensitivity740  ± 1600.29  ± 0.065160  ± 3907

Responses to 50 μM GABA were compared between PP and IL. Responses in IL cells were divided into two groups based on amount of blockade by 0.01 μM DHEAS. Cells in which DHEAS reduced GABA responses to <30% of control were classified as high sensitivity; cells in which GABA responses remained within 60% of control were classified as low sensitivity. D/P was ratio of the end point amplitude of current after desensitization was complete (D) to peak response (P).

  • 1-a Between pooled IL data and PP, all quantities showed statistically significant differences.

  • 1-b Between high and low DHEAS sensitivity IL cells, no quantities showed statistically significant differences.