IC50 values obtained for compounds Pt-berenil and cis-DDP against several ovarian carcinoma cell lines
| Ovarian carcinoma cell line panel (IC50 ± S.D.) | ||||||
|---|---|---|---|---|---|---|
| A2780 | A2780cisR | CH1 | CH1cisR | SKOV-3 | SKOV-3cisR | |
| Pt-berenil | 0.20 ± 0.01 | 0.70 ± 0.04 (3.5) | 0.30 ± 0.03 | 0.36 ± 0.02 (1.2) | 5.20 ± 0.03 | 10.40 ± 0.6 (2) |
| cis-DDP | 0.30 ± 0.02 | 3.30 ± 0.05 (11) | 0.10 ± 0.01 | 0.65 ± 0.05 (6.5) | 4.40 ± 0.03 | 39.60 ± 0.8 (9) |
| Berenil | >10 | >10 | >10 | >10 | >100 | >100 |
Numbers in parentheses, resistance factors: IC50resistant line/IC50 parent line.