Comparison of the parameters for the allosteric interaction of N-chloromethyl brucine with acetylcholine at M2 and M3 receptors measured in binding and functional studies (n = 5).
| Subtype | Binding Studies1-a | Function | ||
|---|---|---|---|---|
| Log Affinity | Cooperativity with ACh | Log Affinity | Cooperativity with ACh | |
| log KX | α | log KX | α | |
| M2 | 4.22 ± 0.11 | 0.09 ± 0.02 | 4.30 ± 0.10 | 0.02 ± 0.01 |
| M3 | 3.66 ± 0.13 | 3.3 ± 0.2 | 3.84 ± 0.02 | 3.8 ± 0.5 |
↵1-a The binding data are from Lazareno et al. (1998).