Drug | HEK-Co Cells | HEK-MRP2 Cells | |
---|---|---|---|
IC50 | IC50 | RR3-a | |
Etoposide (μM) | 0.3 ± 0.1 | 1.2 ± 0.5 | 4.03-b |
Cisplatin (μM) | 2.4 ± 0.6 | 24.2 ± 4.4 | 10.03-b |
Doxorubicin (nM) | 44.3 ± 0.3 | 346.3 ± 48.1 | 7.83-b |
Epirubicin (nM) | 3.8 ± 1.5 | 18.8 ± 2.0 | 5.03-b |
Sensitivity to drugs was determined using MTT cell viability assays as described in Experimental Procedures. All values were obtained in the presence of MDR1 P-glycoprotein inhibitor LY335979 (0.25 μM). Trichostatin A was omitted in this experiment. Data represent the mean ± S.D. (n ≥ 6). The significance of relative resistance factors (RR) was calculated by Student’st test.