Cisplatin adduct levels in A549 monolayers and CultiSphers
| Sample | Cisplatin | Time | pg Pt/100 μg DNA |
|---|---|---|---|
| μg/ml | hr | ||
| Monolayer | 10 | 1 | 5.4 ± 2.9 |
| CultiSpher | 10 | 1 | 5.3 ± 1.5 |
| Monolayer | 10 | 4 | 24.0 ± 2.1 |
| CultiSpher | 10 | 4 | 27.2 ± 0.3 |
| Monolayer | 40 | 4 | 120.3 ± 4.2 |
| CultiSpher | 40 | 4 | 144.4 ± 26.2 |
Pt-DNA adduct formation and platinum accumulation in A549 cells monolayers and CultiSphers using atomic absorption spectroscopy (AAS). Mean value and standard error calculated from two separate trials.