Intracellular cAMP accumulation using a range of CGRP and ADM receptor agonists
| Transfection | Peptide ED50 | |||
|---|---|---|---|---|
| CGRP I | CGRP II | ADM1–52 | ADM13–52 | |
| nM | ||||
| CRLR/RAMP1 | 6.6 ± 2.7 | 7.8 ± 3.6 | 53.5 ± 7.9 | 87.4 ± 8.8 |
| CRLR/RAMP2 | 194.5 ± 61.1 | 21.2 ± 2.3 | 4.7 ± 0.5 | 2.7 ± 0.1 |
| CRLR/RAMP3 | 230.7 ± 50.2 | 35.3 ± 13.0 | 4.1 ± 0.8 | 6.2 ± 0.6 |