Thalamus (Total Benzodiazepine Receptor Population) | Thalamus (α4-containing GABAAReceptors) | α4β3γ2 Cells | |
---|---|---|---|
CGS8216 | 0.30 ± 0.05 | 28 ± 6 | 8.1 ± 1.6 |
Bretazenil | 0.40 ± 0.05 | 59 ± 8 | 36 ± 10 |
DMCM | 8.1 ± 2.6 | 32 ± 7 | 11.3 ± 1.4 |
Ro15-1788 | 3.5 ± 0.4 | 119 ± 25 | 66 ± 9 |
ZK93426 | 0.79 ± 0.11 | 1142 ± 133 | 1386 ± 795 |
Flunitrazepam | 2.9 ± 0.2 | n.d. | 12 ± 1% |
Zolpidem | 20 ± 9 | 12 ± 10% | 4 ± 3% |
Values are the mean ± S.E.M. of two to three determinations. Percentages (%) correspond to the inhibition of [3H]Ro15-4513 binding by 10 μM of the drug.