Table 1

Induction of ICER IR and melatonin production by NE, other neurotransmitters, and drugs

AdditionsICER IRMelatonin Production
% of maximum
Control26.0  ± 1.418.2  ± 1.9
10−6 M NE89.1  ± 2.41-a 77.7  ± 2.01-a
10−6 M AVP25.3  ± 2.223.3  ± 5.2
10−6 M NE/10−6 M AVP78.3  ± 5.61-a 100  ± 0.01-a b
10−6 M NPY18.6  ± 2.218.6  ± 2.2
10−6 M NE/10−6 M NPY82.2  ± 5.156.1  ± 6.21-a d
Control32.8  ± 1.819.2  ± 2.0
10−6 M NE89.3  ± 1.41-a 95.2  ± 2.11-a
10−6 M ADO52.9  ± 2.81-a 35.9  ± 2.1c d f
10−6 M NECA66.9  ± 3.81-a d e 74.2  ± 5.91-a
Control19.7  ± 3.49.3  ± 2.4
10−6 M NE83.8  ± 3.81-a 98.0  ± 2.01-a
10−4 M ACh25.4  ± 3.26.4  ± 1.0
10−6 M NE/10−4 M ACh85.4  ± 3.61-a 88.5  ± 9.41-a
10−3 M glutamate27.0  ± 4.99.6  ± 5.5
10−6 M NE/10−3 M glutamate84.1  ± 3.41-a 47.7  ± 2.11-a b
60 mM KCl40.5  ± 4.413.0  ± 2.1
10−6 M NE/60 mM KCl87.0  ± 3.91-a 56.0  ± 8.71-a d

  • Semiquantitative densitometric analysis of ICER IR and melatonin synthesis expressed as percentage of maximum (n ≥ 3).

  • ↵1-a p < .001 versus control;b p < .01 versus NE;c p < .05 versus NE;d p < .001 versus NE;e p < .05 versus NECA;f p < .001 versus NECA.