Inhibitor | IC50 |
---|---|
OA | PP2A > PP1 > PP2B (PP2A, 0.1 nM; PP1, 10–15 nM; PP2B, 5 μM) |
Calyculin | PP2A = PP1 > PP2B (PP2A, 0.5–1.0 nM; PP1, 2 nM) |
Microcystin-LA | PP1, 2nM; PP2A, 4 pM (does not enter some mammalian cells) |
Tautomycin | PP1 > PP2A > PP2B (PP1 = 1 nM; PP2A, 10 nM) |
Dinophysitoxin (35-methylokadaic acid) | PP2A > PP1 > PP2B |
OTA | Inactive analog of OA |
Relative sensitivities of protein phosphatases to various PP inhibitors are shown.