Ki values for prostanoid ligands at wild type and chimeric receptors
| EP4 | EP2 | EP2/4ECII-C | EP2/4ECIII | |
|---|---|---|---|---|
| PGE2 | 1.2 ± 0.30 | 32 ± 8 | 12 ± 1 | 12 ± 1 |
| PGF2α | 750 ± 110 | 6000 ± 1100 | 7200 ± 1100 | 3600 ± 720 |
| PGD2 | 1100 ± 130 | 10000 ± 3200 | 4800 ± 1300 | 4100 ± 670 |
| Butaprost free acid | Not detected | 1200 ± 400 | 1200 ± 200 | 550 ± 110 |
| AH13205 | Not detected | 1000 ± 140 | 510 ± 150 | 320 ± 85 |
| M&B28767 | 32 ± 7.5 | 5100 ± 1400 | 3300 ± 820 | 1500 ± 410 |
Values are in nM; K i values were calculated from IC50 values.