Effects of various serotonergic receptor agonists on aldosterone secretion from perifused rat adrenal cortex
| Compound | pEC50 | nH | Emax | n |
|---|---|---|---|---|
| 1. 5-CT | 8.23 ± 0.15 | 0.89 ± 0.11 | 605.4 ± 37.6 | 7 |
| 2. Pergolide | 7.44 ± 0.18 | 1.07 ± 0.14 | 679.4 ± 70.6 | 3 |
| 3. 5-HT | 7.20 ± 0.13 | 0.96 ± 0.07 | 707.6 ± 38.9 | 17 |
| 4. 5-MeOT | 5.77 ± 0.21 | 1.12 ± 0.12 | 533.2 ± 14.7 | 8 |
| 5. 5-MeODMT | 5.69 ± 0.22 | 0.68 ± 0.05 | 476.2 ± 66.9 | 3 |
| 6. 8-OH-DPAT | 5.47 ± 0.01 | 1.29 ± 0.27 | 442.2 ± 65.1 | 5 |
| 7. Tryptamine | <5 | 0.97 ± 0.36 | 506.7 ± 33.9 | 6 |
| (±)-DOI | inactive | 3 | ||
| (R,S)-zacopride | inactive | 3 | ||
| BIMU 8 | inactive | 3 |
The effect of each compound on aldosterone secretion was determined as described in Materials and Methods. pEC50 values and efficacy (Emax) of the agonists were determined from semilogarithmic concentration-response curves. Hill coefficient (n H) was calculated for each concentration-response curve. Emax is expressed as the net increase in aldosterone secretion (Δpg/min/adrenal). Values are the mean ± S.E.n indicates the number of independent experiments.