Effect of various serotonergic receptor antagonists on 5-HT-induced aldosterone secretion from perifused rat adrenal cortex
| Compound | [B] | pKB | n |
|---|---|---|---|
| 8. Methiothepin | 0.1 nM | 10.13 ± 0.26 | 8 |
| 9. R(+)Lisuride | 0.1 nM | 9.83 ± 0.42 | 3 |
| R(+)Lisuride | 10 nM | 10.16 ± 0.14 | 3 |
| 10. Pimozide | 0.1 μM | 8.75 ± 0.14 | 6 |
| 11. Metergoline | 0.1 μM | 8.57 ± 0.11 | 5 |
| 12. Clozapine | 0.1 μM | 8.33 ± 0.01 | 4 |
| 13. Mesulergine | 0.1 μM | 8.18 ± 0.05 | 3 |
| 14. Mianserin | 0.1 μM | 7.93 ± 0.11 | 6 |
| Mianserin | 1 μM | 7.27 ± 0.25 | 3 |
| 15. Ketanserin | 0.1 μM | 7.37 ± 0.11 | 5 |
| 16. Cyproheptadine | 0.1 μM | 7.18 ± 0.13 | 3 |
| 17. 1-(1-Naphthyl)piperazine | 0.1 μM | 6.92 ± 0.10 | 3 |
| GR 113808 | 0.1 μM | <5 | 3 |
| GR 113808 | 10 μM | <5 | 2 |
| DAU 6285 | 10 μM | <5 | 2 |
The effect of each compound was determined as described inMaterials and Methods. pK B values of the antagonists were calculated according to Furchgott (1972). Values are the mean ± S.E. n indicates the number of independent experiments.