Agonist | EC50 | Imax | nH | EPMR | N |
---|---|---|---|---|---|
μM | |||||
ATP | 0.7 ± 0.1 | 1.0 | 0.7 | 1 | 9 |
2meSATP | 1.3 ± 0.3 | 1.0 | 1.3 | 1.9 | 9 |
ATPγS | 2.0 ± 0.5 | 0.6 | 1.1 | 2.9 | 6 |
α,β-meATP | 3.1 ± 0.6 | 0.6 | 0.8 | 4.4 | 6 |
ADP | 13 ± 3.3 | 0.8 | 0.9 | 18.6 | 10 |
CTP | 18.6 ± 3.7 | 0.3 | 1.5 | 26.5 | 10 |
EC50 was determined from a three-parameter (EC50,Imax, nH) curve fit to pooled data as described in Materials and Methods; estimates are expressed as mean ± S.D. EPMR, equipotent molar ratio and equals (EC50, test agonist)/(EC50, ATP). N, number of cells contributing to the pooled data for each agonist.