HPRT activity, TPMT activity, and dGs modification of genomic DNA extracted from human leukemia cells after 24 h of exposure to 10 μM MP
| Human Leukemia Cell Lines | HPRT | TPMT | UV Detection |
|---|---|---|---|
| nmol/h/106cells | U/109 cells | pmol dGs/100 pmol dG | |
| T-lineage | |||
| HPRT-deficient CEM | UD | 4.5 ± 0.6 | |
| CEM | 9.4 ± 1.9 | 5.6 ± 1.3 | 0.95 ± 0.05 |
| P12 | 9.3 ± 0.6 | 21.6 ± 3.0 | 0.71 ± 0.5 |
| Molt4 | 12.1 ± 0.6 | 2.6 ± 0.4 | 2.8 ± 0.5 |
| B-lineage | |||
| WIL2S | UD | 1.3 ± 0.3 | |
| WIL2NS | 9.4 ± 2.3 | 10.2 ± 2.1 | 0.48 ± 0.02 |
| 697 | 3.1 ± 0.3 | 8.8 ± 2.1 | 0.045 ± 0.006 |
| NALM6 | 5.6 ± 0.5 | 43.6 ± 2.4 | 0.40 ± 0.045 |
Data represent average of three independent experiments, mean ± SE; UD, undetectable.