[3H]P1075 and [3H]GBC binding to HEK cells transfected with SUR2B and SUR2B + Kir6.1
| [3H]P1075 | [3H]GBC | |||
|---|---|---|---|---|
| KD (P1075) | Ki(GBC) | KD (GBC) | Ki (P1075) | |
| SUR2B | 4.3 (3.5, 5.1) | 1000 (830, 1200) | 32 (16, 65) | 6.6 (5.0, 8.7) |
| SUR2B + Kir6.1 | 5.8 (5.2, 6.3) | 280 (260, 310)1-a | 6.3 (3.5, 11.5) | 3.2 (1.6, 6.4) |
Competition experiments were performed as described in Figs. 1 to 3.K D and K i values (with 95% confidence intervals in parentheses) were calculated from the corresponding IC50 values according to eq. 2 and are given in nanomolar concentrations.
↵1-a Average of the values from cells cotransfected with SUR2B + Kir6.1 at molar plasmid ratios of 1∶1 (269 nM) and 1∶4 (282 nM).