Ki values for ligands in competing for [125I]SCH23982 binding to D1A dopamine receptors in transfected PC2 cell membranes
| Compound | Ki |
|---|---|
| nM | |
| Agonists | |
| Dopamine | 3,800 |
| SKF39393 | 76 |
| Quinpirole | 19,000 |
| Neutral Antagonists | |
| SCH23390 | 0.28 |
| (−)Butaclamol | 9,000 |
| Inverse Agonists | |
| (+)-Butaclamol | 0.8 |
| Chlorpromazine | 25 |
| Clozapine | 20 |
| Fluphenazine | 3 |
| cis-Flupenthixol | 1.2 |
| Haloperidol | 60 |
Membranes prepared from PC2 cells expressing D1A dopamine receptors were incubated with 0.6 nM [125I]SCH23982 with or without increasing concentrations of the listed ligands. Specific D1A dopamine receptor binding was assessed and the inhibitory dissociation constants (K i) were calculated using the LIGAND program. The results were obtained from three independent experiments.