Mutants | N-Methylspiperone | CPPMA | ||||
---|---|---|---|---|---|---|
KD | KDD2/KDmut | n | KI | KID2/KImut | n | |
pM | nM | |||||
D4 | 360 ± 70 | 0.2 | 3 | 0.78 ± 0.28 | 1180 | 7 |
D2 | 79 ± 8 | 1 | 2 | 920 ± 200 | 1 | 6 |
D2V91F/F110L | 280 ± 110 | 0.3 | 2 | 10.5 ± 1.5 | 88 | 4 |
D2V91F/Y408V | 170 ± 8 | 0.5 | 2 | 25 ± 2 | 37 | 4 |
D2F110L/Y408V | 890 ± 40 | 0.1 | 2 | 57 ± 5 | 16 | 3 |
D2V91F/F110L/Y408V | 112 ± 27 | 0.7 | 2 | 6.1 ± 1.2 | 151 | 4 |
D2V91F/F110L/V111M/Y408V | 360 ± 8 | 0.2 | 2 | 0.19 ± 0.06 | 4842 | 4 |
D2W90L/V91F/L94S/F110L/V111M/Y408V | 960 ± 140 | 0.1 | 4 | 0.48 ± 0.14 | 1840 | 4 |
K D values and K I values were calculated as described in Experimental Procedures. Data are means ± S.E.