Table 1

Functional potencies of human P2X₂ receptor agonists and antagonists

pEC₅₀^1-a	hP2X_2a	hP2X_2b
ATPγS	5.87 ± 0.02	5.68 ± 0.01
ATP	5.99 ± 0.01	5.83 ± 0.02
2-meS-ATP	6.09 ± 0.02	6.1 ± 0.02
BzATP	6.38 ± 0.03	5.96 ± 0.42
α,β-meATP	>4	>4
ADP	>4	>4
ADPβS	4.51 ± 0.11	4.38 ± 0.12
UTP	>4	>4
PPADS^1-b	5.46 ± 0.62	5.65 ± 0.04

↵1-a Ligand potencies were determined in three or more replicate assays.
↵1-b PPADS pIC₅₀ was determined in the presence of 5 μM ATP.