Receptor Subtype | Ki | |||
---|---|---|---|---|
d-Fenfluramine | l-Fenfluramine | d-Norfenfluramine | l-Norfenfluramine | |
nM | ||||
5-HT2A | 2470 ± 240 | 1430 ± 330 | 187 ± 10 | 267 ± 16 |
5-HT2C | 2080 ± 480 | 1620 ± 340 | 56 ± 19 | 99 ± 12 |
5-HT2B | 3920 ± 830 | 680 ± 16 | 27 ± 7 | 65 ± 23 |
Competition experiments were conducted as described in Materials and Methods. Depicted are mean ± S.E. K ivalues of enantiomers of fenfluramine and norfenfluramine versus [125I]DOI for the 5-HT2A and 5-HT2C receptor or [3H]LSD binding for the 5-HT2B receptor (from three to six independent experiments).