Table 1

NMR data for RPR112378

Atom		¹H^1-a	¹³C^1-b	HMBC^1-c	nOe^1-d
1	2.85 dd	J=8.5; 6	51.3	C₂; C₇; C₉; C₁₃	9/13, 13, 8a, 6
2			200
3	5.94 d	J=10	128.2	C₅	4
4	7 d	J=10	145.7	C₂; C₅; C₁₀; C₆	3, 10
5			141.7
6	2.78 t	J=8.5	48.4	C₂; C₅; C₁₀; C₁₁; C₁	1, 8a, 10, 11, 12
7	2.62 q	J=8.5	48.8	C₁₂; C₅; C₆	8a, 8b, 10, 12
8a	1.55 m		35.5	C₁₁; C₁; C₆; C₉; C₁₃	8b, 9/13, 11, 1, 12
8b	1.75 m			C₁₁; C₆; C₉; C₁₃	8a, 13, 9/13, 7, 3′
9	2.5 m		46	C₁; C₁₃	Overlap with 13
10	5.3 m	(2H)	119.7	C₄; C₅; C₆	6, 7, 4, 12
11	5.75 m		142.8
12	4.95 m	(2H)	114.2	C₇	7, 10, 8a, 6
13	3.05 m		35.7	C₄′; C₃′; C₅′; C₉; C₈	3′, 5′, 9/13, 8b, 1
13	2.5 m			C₄′; C₃′; C₅′; C₉; C₈	Overlap with 9
1′			144.5
2′			145.2
3′	6.76 d	J=2	114.8	C₁′; C₅′; C₁₃	OH, 13, 9/13, 8b
4′			135
5′	6.68 dd	J=8; 2	120.1	C₁′; C₃′; C₁₃	13, 9/13
6′	6.74 d	J=8	110.3	C₂′; C₄′	OCH₃
OCH₃	3.85 s		55.8	C₁′	6′, OH
OH	5.50 s			C₂′; C₃′	OCH₃, 3′

↵1-a 600 MHz, CDCl₃, δ in ppm, J in Hz. All assignments are supported by correlation spectroscopy (COSY).
↵1-b 150 MHz, CDCl₃, δ in ppm. All assignments are supported by heteronuclear multiple-quantum correlation (HMQC) and heteronuclear multiple-bond connectivities (HMBC) experiments.
↵1-c 600 MHz, CDCl₃, ¹H correlations to carbon atoms.
↵1-d 400 MHz, CDCl₃, (m = 300 ms) ¹H correlations to other ¹H atoms.