Table 1

Platinum drug sensitivity of transfected A2780 human ovarian cancer cells determined by SRB growth delay assay

Cell LineIC50
Cisplatin1-aTransplatin1-aZD04731-aJM3351-a
μM
Parental A27801.58  ± 0.061-150 N.D.N.D.N.D.
VC1.90  ± 0.081-150,1-160 129  ± 20.81-165 7.73  ± 0.371-160 1.87  ± 0.131-150
E60.63  ± 0.071-160 50.9  ± 11.11-165 2.42  ± 0.141.25  ± 0.201-150

  • ↵1-a Values are mean ± S.E. for data from three independent experiments with four values for each.

  • ↵1-150  No significant difference between values.

  • ↵1-160  P < .01.

  • ↵1-165  P < .05.

  • N.D., not determined.