Table 2

Summary of the effects of altering p53 status on cisplatin sensitivity

Cell Line	p53 Status of Cell Line^2-a	Transfection^2-b	Change in Cisplatin Sensitivity	Reference
Human foreskin fibroblasts	WT	HPV-16 E6	Sensitive	Hawkins et al., 1996
MCF-7 (breast)	WT	HPV-16 E6	Sensitive	Fan et al., 1995
		Dom neg p53	Sensitive	Fan et al., 1995
RKO (colon)	WT	HPV-16 E6	Sensitive	Fan et al., 1995
PA-1 (ovarian)	WT	HPV-16 E6	Resistant	Wu and El Diery, 1996
HCT116 (colon)	WT	HPV-16 E6	Sensitive	Fan et al., 1997
Lymphoblastoid	WT	Dom neg p53	Resistant	Piovesan et al., 1998
A2780 (ovarian)	WT	Dom neg p53	Resistant	Brown et al., 1993; Herod et al., 1996
AsPC-1 (pancreatic)	MT	WT p53	No change	Kimura et al., 1997
HL60	MT	WT p53	Sensitive	Ju et al., 1998
SKOV-3 (ovarian)	Null	WT p53	No change	Graniela Siré et al., 1995
		Dom neg p53	No change

↵2-a p53 status of cell line before transfection: WT, wild type; MT, mutant.
↵2-b Gene transfected: Dom neg p53: dominant negativep53 mutant transcript; WT, wild-type p53 transcript.