Table 1

Cross-resistance profile at 35°C of JN394t2-4 transformed with wild-type and mutant TOP2α alleles

Plasmid	Mutation in Topoisomerase IIα	MLC
Plasmid	Mutation in Topoisomerase IIα	Amsacrine	Etoposide^1-a	Ellipticine^1-b	Doxorubicin
		μg/mL
YEpWOB6	Wild-type	1	50 ± 25	25, 15	10
YEpWOB6-A1F	E571K	>25	100	25, 20	ND
YEpWOB6-A2F	R486K	>100	166 ± 28^1-150	25, 20	10