Table 1

Sensitivity of HIV-1 wild-type Trp-229 RT, 229Phe RT, and 229Tyr RT to the inhibitory effects of NNRTIs and ddGTP

IC₅₀^1-a
NNRTI	Trp-229	229Phe	229Tyr
	μM
Nevirapine	6.16 ± 0.3	8 ± 4	16.7 ± 0.3
Delavirdine	0.66 ± 0.04	0.6 ± 0.3	1.6 ± 0.9
Efavirenz	0.02 ± 0.01	0.025 ± 0.003	0.02 ± 0.00
Emivirine	0.122 ± 0.007	0.13 ± 0.02	1.03 ± 0.09
HBY 097	0.014 ± 0.002	0.0162 ± 0.0002	0.020 ± 0.006
GW 420867	0.04 ± 0.02	0.08 ± 0.05	0.19 ± 0.09
UC-781	0.022 ± 0.001	0.035 ± 0.009	0.48 ± 0.38
ddGTP	0.42 ± 0.04	0.68 ± 0.09	0.57 ± 0.12

↵1-a IC₅₀, or 50% inhibitory concentration required to inhibit the enzyme activity by 50%, using poly(C) · oligo(dG) as the template-primer and (2,8−³H)dGTP as the radiolabeled substrate. The data are means of at least two independent experiments.