Whole-cell currents activated by GABA
| Receptor | Ip | T10–90 | T50 |
|---|---|---|---|
| pA | ms | ||
| αβ (WT) | 3370 ± 612 | 16 ± 2 (6) | 223 ± 43 (6) |
| α(L9′F)β | 765 ± 90 (15) | 7 ± 1 (15) | 55 ± 5 (15) |
| αβ(L9′F)1-a | 3958 ± 687 (6) | 12 ± 1 (6) | 290 ± 27 (6) |
| α(L9′F)β(L9′F) | 365 ± 68 (8) | 9 ± 1 (8) | 27 ± 3 (8) |
| α(L9′Y)β | 672 ± 148 (12) | 10 ± 1 (12) | 78 ± 10 (12) |
| αβ(L9′Y)1-a | 1428 ± 204 (5) | 11 ± 1 (5) | 337 ± 29 (5) |
| α(L9′Y)β(L9′Y) | 172 ± 26 (7) | 9 ± 1 (7) | 12 ± 1 (7) |
| αβ(L9′A) | 1017 ± 223 (8) | 7 ± 1 (3) | 1400 ± 200 (3) |
| α(L9′A)β(L9′A) | 107 ± 15 (6) | 559 ± 220 (5) | No desensitization |
| α(L9′T)β1-b | 407 ± 53 (5) | 116 ± 15 (5) | 2140 ± 200 (5) |
Characteristics of whole-cell currents activated by 10 mM or1-a30 mM
GABA concentrations are summarized for cells expressing either mutated or wild-type (WT) receptors. Values are expressed as mean ± 1 S.E. The number of cells used is shown in parentheses.Ip is the value of the peak current;T10–90 is the time taken for the peak current to increase from 10 to 90% of the maximum current; T50is the time taken for the peak current to decay by 50%.