Table 1

Summary of K_m values for wild-type and mutant enzymes

Enzyme	K_m (mM)	RelativeK_cat/K_m^1-a
WT T. californicaAChE	0.061 ± 0.004	1
WT mouse AChE	0.051 ± 0.008	1
Mouse Y330A	0.16 ± 0.02	0.15
Mouse Y330F	0.16 ± 0.02	0.43
WT mouse BChE	0.16 ± 0.03
Mouse AChE F288L	0.052 ± 0.004	0.3
Mouse AChE F290I	0.19 ± 0.02	0.03
T. californica AChE F288L/F290V	0.101 ± 0.009	0.1

↵1-a With wild-type taken as 1; taken from references Harel et al. (1992) and Radic et al. (1993).
WT, wild-type.