Table 2

Inhibition of adenylate cyclase activity after long-term exposure (24 h) of SHSY5Y cells to DAMGO (10 μM) or BUBU (10 μM)

TreatmentsAdenylate Cyclase Inhibition by
DAMGODPDPE
%
Control41.33  ± 4.4847.33  ± 5.3
DAMGO4.67  ± 2.722-150 35.02  ± 6.66
BUBU36.23  ± 6.546.33  ± 5.252-150

Results represent the maximal inhibition observed in presence of DAMGO (10 μM) or DPDPE (10 μM) compared to basal activity, mean ± S.E. of three independent experiments performed in triplicate.

    • 2-150 P < .01 compared with control cells.